Sisel Is Changing Lives
Harvard Scientists REVERSE Aging In Mice. People Next...
Harvard may have just discovered the real life fountain of youth ..
treatment with the NAD precursor NMN mitigates age-related DNA damage
NAD+ stands for nicotinamide adenine dinucleotide
THE A.G.E. PILL IS MORE THAN JUST NAD+
The Science Behind The A.G.E. Pill
Glycation and Ageing
The term A.G.E. is actually an acronym for "Anti Glycation Extreme". So what is glycation? Glycation is what occurs when blood glucose molecules bond with protein molecules in our bodies. The pathological impact of unavoidable phenomenon is the formation of something called an advanced glycation end product. This happens to all of us ... slowly ... over a lifetime.
As children we had all the energy we needed, all day long. This energy is derived from metabolizing glucose sugar. As our bodies break down the glucose, the oxidation process releases the energy that powers the cells in our body. But unfortunately, a plaque-like residue is left over and forms a coating over the cells. This oxidized glucose plaque is called "glycation".
You can observe the effects of acute glycation in
diabetes patients. People suffering from diabetes
tend to age faster and along with that they experience
the early onset of degenerative diseases. This is due
to poor sugar control.
At some level, the same thing is happening to every single one of us - just not to the same extreme, nor at the same rate. So in short, "glycation" is the result of lifelong glucose exposure - the metabolism of which is essential for life and energy, but it comes with this pathological "side effect". The buildup of this plaque-like substance also interferes with inter-cellular (cell-to-cell) communication.
Science now understands Ageing
more than ever before
Telomere attrition
Inflammation
AMPK inactivity
DNA repair
Glycation
Gene expression
Loss of protein synthesis
Endothelial dysfunciton
Mitochondrial dysfuntion
Stem cell deactivation
Immune senescence
Lipofuscin deposition
Dr Jerry Shaw: Message Intended for Doctors
Click arrow below
The Vital Role of Stem Cells
Now let's talk about stem cells. When we are young, our bodies grow quickly. We have an abundance of stem cells which are highly productive. These stem cells are the "master cells" in our bodies that are able to transform into any type of cell that we need. As we grow the stem cells divide and multiply into the trillions of cells that comprise an adult body. Our stem cells also replace the cells in our bodies that wear out.
But when glycation occurs and plaque-like metabolized glucose residues attach themselves
to the proteins in our stem cells, they create a kind of "barrier" or film over the stem cells so that
they slowly lose their efficiency and functionality. As a consequence, a cellular "sludge" forms
inside the cells over time. The scientific name for this is "lipofuscin".
The lipofuscin 'sludge' buildup interferes with intra-cellular communication, both in our 'regular'
cells, as well as our stem cells so that they can no longer do the job they are supposed to do.
As a consequence, the cell mitochondria are damaged - and because the mitochondria are
damaged - and because the mitochondria are like the 'nuclear power plants' of our cells, we then
find ourselves lacking energy.
Lack of energy and slowing down of regular bodily functions are the typical symptoms of ageing - lack of muscle strength, memory loss, etc. Cell regeneration is inhibited, so that we no longer create as many cells as we lose in a day. This is what ageing is. Ageing is not a disease - it is a process.
To reverse ageing, we need a way to get back to 1:1 cell regeneration and efficient cell functionality. This is how it used to be when you were 20-25. Once you cross the 30 year old threshold you begin to lose more cells than you create - and the cells that you do have don't function internally as efficiently as the used to.
When lipofuscin caused by glycation is removed, when the cellular garbage is taken out of the stem cells, the mitochondria within the cells now have the ability to react by creating massive amounts of energy molecules and biological hydrogen, which combines with the electrical energy of the body to make you feel like you have the energy of a teenager once again.
Glycation is one of the most significant causes of poor aging. AGEs Advanced glycation end products are harmful compounds. They accumulate naturally as you age and are created when certain foods are cooked at high temperatures.
Often found in humans starting at the age of 40, these spots are deposits of a brownish pigment called lipofuscin, considered to be one of the aging or "wear-and-tear" pigments, found in the liver, kidney, heart muscle, retina, adrenals, nerve cells and ganglion cells.
The “powerhouses of the cell”, that’s how many people refer to the mitochondria. The parts of cells that turn sugars, fats and proteins that we eat, into forms of chemical energy that the body can use to carry on living.
The Rate at Which We Age
Scientific research indicates that at the 30-40 age range the rate of aging increases by approximately 1.2 years per for every chronological year lived. Using this model: by age 40-59 the 0.2 accelerated aging factors are added to the 1.2 aging rate previously calculated for the 30-40 year old range. Consequently the rate of aging between 40-50 is now 1.4 years for every year lived. It is important to note that this 0.2 rate continues to accelerate, adding on to every 10 year increment.
Let's chart this ratio of decay and degeneration comparing chronological
age vs biological at 1.2 days lived since a person was 30 years old:
AGE Pill Breakthrough Science - with Formulator Tom Mower
Click arrow below to play / pause
1. 30 years aging @ 1.2 days each day at age 40 = 46 years old
2. 40-50 yrs aging @ 1.4 days each day at age 50 = 66 years old
3. 50-60 yrs aging @ 1.6 days each day at age 60 = 96 years old
4. 60-70 yrs aging @ 1.8 days each day at age 70 = 126 years old
5. 70-80 yrs aging @ 2.0 days each day at age 80 = 140 years old
6. 80+ or older. Maybe put jelly in your pockets because you are toast.
HOWEVER all is not lost for The A.G.E. PILL can put you on the track
to go the other way, no matter what your age.
27 min.
How Long Does The Body Take To Renew:
STOMACH LINING five (5) days
SKIN one (1) month
LIVER six (6) weeks
DNA two (2) months
NERVOUS SYSTEM three (3) months
BLOOD four (4) months
BLOOD VESSEL LINING six (6) months
MUSCLES seven (7) months
BRAIN one (1) year
SKELETON eleven (11) months
It doesn't happen overnight. It's a process - but most people are experiencing noticeable results within a month,
especially when drinking sufficient water in order to facilitate the process of flushing.
The A.G.E. Pill Ingredients
What they can do for the body
Aging is an accumulation of things that happen at a cellular level as we live longer. The aging process is not a disease – it is simply the decay and degeneration of our cells, resulting in reduced functionality. This process beings at age 23 in women and 25 in men. We lose about 8-10% of our physical being and biological functions every ten years.
The Chinese knew how to slow down aging 1000’s of years ago. By removing toxins and wastes and assimilating super nutrients that are specialized for certain biological processes, the body has the ability to live a very long time. Sisel’s AGE pill does this in three different, yet synergistic, ways. Firstly, it ends cell decay; second, it eliminates waste within the cell and third, it regenerates stem cells.
Beta-Alanine
Beta-alanine is a naturally occurring beta amino acid that is converted to other chemicals that can then affect the muscles. This has been shown to enhance muscular endurance.
Beta- Alanine supplementation can also improve moderate to high intensity cardiovascular exercise performance, like rowing or sprinting. When beta-alanine is ingested, it turns into the molecule carnosine, which acts as an acid buffer in the body. Carnosine is stored in cells and releases in response to drops in the pH. Increased stores of carnosine can protect against diet induced drops in the pH as well as offer protection from exercise induced lactic acid production. Carnosine also shows reduction of oxidative stress and glycation products. Rated one of the number one protein supplements for muscle support.
Alpha-Lipoic Acid (ALA)
-is found in the body and also synthesized by plants and animals. Its present in every cell of the body and helps turn glucose into fuel for the body to run off of. Its most valuable role is fighting the effects of free radicals which are dangerous chemical reaction byproducts that form during the process of oxidation. Within our cells, ALA is converted into dihydrolipoic acid, which has protective effects over normal cellular reactions. Like other antioxidants ALA can help to slow down cellular damage that is one of the root causes of diseases like cancer, heart disease and diabetes. It also works in the body to restore essential vitamin levels, such as vit E and Vit C, along with helping the body digest and utilize carbohydrate molecules while turning them into usable energy.
ALA is both water soluble and fat soluble unlike other nutrients which can only be properly absorbed with either one or the other. There is some evidence that ALA acts as a heavy metal chelator, binding metals in the body. ALA can increase how the body uses glutathione, and it might increase energy metabolism as well- which is why this supplement is often used by athletes to enhance physical performance.
ALA can protect cells and neurons involved in hormone production, one benefit is it offers protection against diabetes. Because alpha lipoic acid can protect cells and neurons involved in hormone production, one benefit is it offers protection against diabetes. ALA is considered an effective drug in the treatment of diabetic distal sensory-motor neuropathy, which affects about 50 percent of people with diabetes. (5) In dietary supplement form, ALA seems to help improve insulin sensitivity and might also offer protection against metabolic syndrome — a term given to a cluster of conditions like high blood pressure, cholesterol and body weight. Some evidence also shows that it can help lower blood sugar levels.
ALA is used to help relieve complications and symptoms of diabetes caused by nerve damage, including numbness in the legs and arms, cardiovascular problems, eye-related disorders, pain, and swelling. That’s why it should be part of any diabetic diet plan to treat this common disorder. People who experience peripheral neuropathy as a side effect of diabetes can find relief from pain, burning, itching, tingling and numbness using ALA, although most studies show that high doses in IV form are most effective as opposed to eating ALA-rich foods.
A major benefit of alpha lipoic supplementation in diabetics is the lowered risk for neuropathic complications that affect the heart, since around 25 percent of people with diabetes develop cardiovascular autonomic neuropathy (CAN). CAN is characterized by reduced heart rate variability and is associated with an increased risk of mortality in people with diabetes. Oxidative stress can damage nerves in the eyes and cause vision problems, especially in people with diabetes or older adults. Alpha lipoic acid has been used successfully to help control symptoms of eye-related disorders, including vision loss, macular degeneration, retina damage, cataracts, glaucoma and Wilson’s disease.
Results from certain studies demonstrate that long-term use of alphalipoic acid has beneficial effects on the development of retinopathy since it halts oxidative damage that can result in modified DNA in the retina.
DMAE (dimethylaminoethanol)
DMAE is a substance naturally produced in small amounts in the brain and also found in anchovies and sardines. DMAE supplements are promoted to boost brainpower, improve memory, and slow aging. The idea that DMAE can improve memory stems from research suggesting it may increase levels of the neurotransmitter acetylcholine, which is believed to play an important role in learning and memory.
Levels of acetylcholine decline among people with Alzheimer’s disease, and the drugs used to treat Alzheimer’s patients target the processes that break it down. DMAE has also been studied as a means of relieving the symptoms of tardive dyskinesia, a spastic disorder that is a side-effect of long-term use of some anti-psychotic medications. Despite some promising preliminary studies, subsequent research failed to confirm that DMAE had any effect.
DMAE Bitartrate is a powdered form of the compound Dimethylaminoethanol (also known as DMAE or Deanol), a naturally occurring compound in the brain. DMAE is a precursor to the neurotransmitter choline. … Choline has been shown to directly influence the areas of learning and memory. DMAE bitatrate is particularly beneficial for your memory function cal also increase mental adaptability, concentration, brain cell health and give you better analytic processing skills as well. DMAE is a compound that is known as a mind health compound.
It does this by reducing buildup of what is known as the ‘age pigment’, which impairs cognitive function and is implicated in the cognitive decline with age. It can also increase levels of the compound involved with memory, acetylcholine.
It can also protect neurons and other cells from harmful effects of certain types of oxidation by embedding itself in the structure of the cell and acting as an anti-oxidant, as well as sustaining metabolic processes in the body through a process known as ‘methyl donation’.
DMAE is also found in various face and body creams, and can tighten and tone skin quality.
L-Carnosine
Carnosine (beta-alanyl-L-histidine), featuring the characteristic Imidazole-ring, is a dipeptide molecule, made up of the amino acids beta-alanine and histidine. It is highly concentrated in muscle and brain tissues. L-Carnosine acts as an anti-glycating agent, reducing the rate of formation of advanced glycation end-products (AGEs) (substances that can be a factor in the development or worsening of many degenerative diseases, such as diabetes, atherosclerosis, chronic renal failure, and Alzheimer’s disease), and ultimately reducing development of atherosclerotic plaque build-up.
Chronic glycolysis is speculated to accelerate aging, making L-Carnosine a candidate for therapeutic potential. L-carnosine, sometimes called simply carnosine, is a combination of two amino acids, alanine and histidine. Your body manufactures carnosine, found in high concentrations in skeletal muscle, the lenses of the eyes, the brain and the nervous system. Carnosine acts as an anti-oxidant, a substance that neutralizes free radicals, which damage cells. potential benefits on the fact that carnosine inhibits advanced glycation end products, called AGEs, which contribute to Alzheimer’s disease.
One study found that in rat lenses exposed to substances that induce cataract formation and carnosine, carnosine prevented or reversed cataracts (Biochemistry study 5/14/2009). L-Carnosine may be recommended as an adjunct therapy for diabetes mellitus or autism. This supplement has also been researched for its antiglycation, antioxidant, cardioprotective, anticancer and antidiabetic effects. In humans, carnosine is naturally found in the brain, skeletal muscles, the heart and certain other innervated organs and tissues.
L-Carnosine supports athletic performance and muscle vitality as well. A number of experiments carried out in Australia showed that Carnosine reinvigorates cells as they approach senescence (the stage just before they die when the cell is not functioning). Cells were given Carnosine actually looked and behaved younger than untreated cell’s .
Importantly, Carnosine reversed the signs of aging in these senescent (nearly dead) cells. This means that Carnosine is a great for older people who want to look younger, as well as those who want to continue looking younger.
L-Carnosine limits the formation of oxidized sugars, commonly known as Advanced Glycosylation End-products (AGEs) by acting as an antioxidant. From an anti-aging perspective, the fewer AGEs created in your body the better. Carnosine prevents lipid, DNA, and protein damage by removing harmful metals via chelation. Carnosine may prevent Alzheimer’s by counteracting the build up of aldehydes and amyloid plaques, which are widely considered to be the primary causes of Alzheimer’s .
The aggregation of beta amyloid into fibrillar structures contributed to Alzheimer’s disease. Carnosine was found to impede the formation of fibrillar structures by altering the hydrogen bond network involved in fibrillogenesis . By protecting the brain against free radicals and advanced glycation end products carnosine may provide a useful tool for tackling Alzheimer's.
Betaine Hcl
Betaine hydrochloride is an acidic form of betaine, a vitamin-like substance found in grains and other foods. Betaine hydrochloride is recommended by some doctors as a supplemental source of hydrochloric acid for people who have a deficiency of stomach acid production (hypochlorhydria). In biological systems, many naturally occurring betaines serve as organic osmolytes, substances synthesized or taken up from the environment by cells for protection against osmotic stress, drought, high salinity or high temperature.
Intracellular accumulation of betaines, non-perturbing to enzyme function, protein structure and membrane integrity, permits water retention in cells, thus protecting from the effects of dehydration. It is also a methyl donor of increasingly recognised significance in biology.
Acetyl L-Carnitine
Acetyl L-carnitine (ALC) is an amino acid that’s primarily used by the body for energy production but also helps create acetylcholine, a brain chemical associated with memory and cognitive function.* It’s been shown to help mental fatigue associated with aging.*
Acetyl-L-Carnitine is an amino acid the body uses to turn fat into energy. It is not normally considered an essential nutrient because the body can manufacture all it needs. However, supplemental L-Carnitine may improve the ability of certain tissues to produce energy. This effect has led to the use of L-Carnitine in various muscle diseases as well as heart conditions.
Additionally, a preliminary study suggests that L-Carnitine may be useful for improving blood sugar control in individuals with type 2 (adult-onset) diabetes. It also might help prevent diabetic cardiac autonomic neuropathy (injury to the nerves of the heart caused by diabetes). Weak evidence suggests that L-Carnitine may be able to improve cholesterol and triglyceride levels, and also help individuals with degeneration of the cerebellum (the structure of the brain responsible for voluntary muscular movement).
One very small study suggests L-Carnitine may be helpful for reducing symptoms of chronic fatigue syndrome. Another study suggests that L-Carnitine may be of value for treating hyperthyroidism. Acetyl L-carnitine Hcl is a potent super nutrient that supports the body in the same wat as L-carnitne but also has the ability to pass through the blood brain barrier. Supports mental sharpness by stimulating acetylcholine production. It has been shown to help maintain cellular stability and to promote cell membrane health.
Cellular energy production itself produces free radicals that can harm cell structures, including the mitochondria, if the body’s natural antioxidant capacity is low. Acetyl l-carnitine and lipoic acid are both naturally present antioxidants in the body that have been shown to support mitochondrial function and help reduce free radical damage.
(Hagen TM et al., 1998; Lyckesfeldt J et al., 1998) Acetyl l-carnitine HCL enhances energy production by promoting the transport of fatty acids into the energy-producing units in the cells. In two animal studies from the University of California at Berkeley (Hagen TM et al., 1998) acetyl l-carnitine significantly benefited mitochondrial health and promoted increased cellular respiration and membrane health.
L-5-Hydroxytryptophan (5-HTP)
5-HTP is the precursor of the neurotransmitter serotonin. 5-HTP is obtained from the seeds of the plant Griffonia simplicifolia. also known as oxitriptan (INN), is a naturally occurring amino acid and chemical precursor as well as a metabolic intermediate in the biosynthesis of the neurotransmitter serotonin.
5-HTP has been suggested as a treatment for many conditions. Some research supports the use of 5-HTP in treating cerebellar ataxia, headache, depression, psychiatric disorders, and fibromyalgia, and as an appetite suppressant or weight loss agent. Parkinson’s disease is a neurological disorder that usually develops around the age of 50. The disorder occurs when the brain cells that make dopamine slowly degenerate. Symptoms include tremors (shaking) and difficulties with movement and coordination. 5-HTP has been studied, usually in combination with drugs, for Parkinson’s disease.
Widely used to help with obesity (dieting), PMS, migraines, depression, anxiety, insomnia and addictive behaviour, 5 HTP increases production of serotonin. Serotonin levels in the nervous system are essential for so many aspects of our daily lives. Serotonin is responsible for feelings of well being, satisfaction and for normal sleep patterns. Obesity, PMS, migraines, depression, anxiety, insomnia and addictive behavior have all been associated with low levels of serotonin. Serotonin plays an important role in controlling anger, aggression, body temperature, mood, sleep, human sexuality, appetite, and metabolism, as well as stimulating vomiting. Clinical studies have shown that supplementing with 5-HTP produces positive results in weight loss, anxiety and depression.
Blueberry Fruit
They protect our bodies from damage by free radicals, unstable molecules that can damage cellular structures and contribute to aging and diseases like cancer.
Blueberries are believed to contain the highest antioxidant capacity of ALL commonly consumed fruits and vegetables. The main antioxidant compounds in blueberries belong to a large family of polyphenols, called flavonoids. One group of flavonoids in particular, anthocyanins, is thought to be responsible for much of the beneficial health effects. They have been shown to directly increase antioxidant levels inside the body. Because blueberries are high in antioxidants, they can help neutralize some of the free radicals that cause damage to our DNA.
Nicotinamide Riboside
Nicotinamide riboside (NR) is a pyridine-nucleoside form of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide or NAD+. NR has been a recent focus of life extension research after Dr. David Sinclair published a study in 2013 showing NAD+ levels decrease with age in mice.
Nicotinamide riboside is a precursor to NAD+ and could be the world’s best way to synthetize NAD+ within our bodies. Nicotinamide riboside is naturally produced in our bodies. It’s a chemical compound which acts as a precursor to vitamin B3 (pyridine-nucleoside).
Nicotinamide riboside promotes mitochondrial biogenesis to turn back the effects of aging. Mitochondria is directly linked to aging. As our bodies age, our mitochondrial production – and functionality – declines. This leads to a wide range of degenerative diseases and ultimately makes us look and feel older.
